Within the context of biomedicine and pharmaceutical sciences, the issue of (therapeutic)
protein stabilization assumes particular relevance. Stabilization of protein and protein-like …

In the area of peptide and protein pharmaceuticals, both the physical and chemical stability
of biopharmaceuticals are critical and need to be optimised when formulating a drug …

Osmolytes are naturally occurring small molecules accumulated intracellularly to protect
organisms from various denaturing stresses. Similar to the two faces of a coin, several of …

Homocystinuria is a disorder of sulfur metabolism pathway caused by deficiency of
cystathionine β-synthase (CBS). It is characterized by increased accumulation of …

Complex coacervation can be used as a route to compartmentalize a variety of solutes such
as organic small molecules, inorganic nanoparticles, and proteins within microscale …

Osmolytes are small molecules that are exploited by cells as a protective system against
stress conditions. They favour compact protein states which makes them stabilize globular …

Insulin and its homologous are the most utilized protein drugs due to their role in diabetic
patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the …

The Hofmeister series is a universal homologous series to rank ion-specific effects on
biomolecular properties such as protein stability or aggregation propensity. Although this …

Many studies aimed at advancing our understanding of the mechanisms of protein
stabilization that support the survival of organisms under harsh environmental conditions are …

It is well-known that the typical protein's three-dimensional structure is relatively unstable in
harsh conditions. A practical approach to maintain the folded state and thus improve the …