Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

Y Tan, Z Zhang, C Zheng, KA Wintergerst… - Nature Reviews …, 2020 - nature.com
The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …

Screening for type 1 diabetes in the general population: a status report and perspective

EK Sims, REJ Besser, C Dayan… - Diabetes, 2022 - Am Diabetes Assoc
Most screening programs to identify individuals at risk for type 1 diabetes have targeted
relatives of people living with the disease to improve yield and feasibility. However,∼ 90 …

Consensus guidance for monitoring individuals with islet autoantibody–positive pre-stage 3 type 1 diabetes

M Phillip, P Achenbach, A Addala… - Diabetes …, 2024 - diabetesjournals.org
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at
the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay …

Type 1 diabetes—early life origins and changing epidemiology

JM Norris, RK Johnson, LC Stene - The lancet Diabetes & …, 2020 - thelancet.com
Type 1 diabetes is a chronic, immune-mediated disease characterised by the destruction of
insulin-producing cells. Standardised registry data show that type 1 diabetes incidence has …

Type 1 diabetes mellitus

A Katsarou, S Gudbjörnsdottir, A Rawshani… - Nature reviews Disease …, 2017 - nature.com
Type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, is a chronic disease
characterized by insulin deficiency due to pancreatic β-cell loss and leads to …

Genetic risk factors for type 1 diabetes

F Pociot, Å Lernmark - The Lancet, 2016 - thelancet.com
Type 1 diabetes is diagnosed at the end of a prodrome of β-cell autoimmunity. The disease
is most likely triggered at an early age by autoantibodies primarily directed against insulin or …

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children

AG Ziegler, M Rewers, O Simell, T Simell, J Lempainen… - Jama, 2013 - jamanetwork.com
Importance Type 1 diabetes usually has a preclinical phase identified by circulating islet
autoantibodies, but the rate of progression to diabetes after seroconversion to islet …

Genetics of type 1 diabetes

MJ Redondo, AK Steck, A Pugliese - Pediatric diabetes, 2018 - Wiley Online Library
Type 1 diabetes (T1D) results from immune‐mediated loss of pancreatic beta cells leading
to insulin deficiency. It is the most common form of diabetes in children, and its incidence is …

Yield of a public health screening of children for islet autoantibodies in Bavaria, Germany

AG Ziegler, K Kick, E Bonifacio, F Haupt, M Hippich… - Jama, 2020 - jamanetwork.com
Importance Public health screening for type 1 diabetes in its presymptomatic stages may
reduce disease severity and burden on a population level. Objective To determine the …

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association

RA Insel, JL Dunne, MA Atkinson, JL Chiang… - Diabetes …, 2015 - Am Diabetes Assoc
Insights from prospective, longitudinal studies of individuals at risk for developing type 1
diabetes have demonstrated that the disease is a continuum that progresses sequentially at …