Traumatic brain injury (TBI) leads to post-traumatic epilepsy (PTE); hence, both TBI and PTE
share various similar molecular mechanisms. MicroRNA (miRNA) is a small noncoding RNA …

Background Given that new therapeutic options for spinocerebellar ataxias are on the
horizon, there is a need for markers that reflect disease‐related alterations, in particular, in …

The prevalence estimations of hereditary ataxias are biased since most epidemiological
studies are confined to isolated geographical regions and few nationwide studies are …

Background and Objectives In spinocerebellar ataxia, ataxia onset can be preceded by mild
clinical manifestation, cerebellar and/or brainstem alterations, or biomarker modifications …

Abstract Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused
by abnormal expansion of glutamine-encoding CAG repeats in the Ataxin-1 (ATXN1) gene …

Background In polyglutamine (polyQ) diseases, the identification of modifiers and the
construction of prediction model for progression facilitate genetic counseling, clinical …

Abstract Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, dominantly inherited
neurodegenerative disease caused by the expanded polyQ tract in the protein ATAXIN1 …

Spinocerebellar ataxias (SCAs), formerly known as autosomal dominant cerebellar ataxias
(ADCAs), are a group of hereditary heterogeneous neurodegenerative diseases. Gait …

While astrocyte heterogeneity is an important feature of the healthy brain, less is understood
about spatiotemporal heterogeneity of astrocytes in brain disease. Spinocerebellar ataxia …

Objective The aim was to study the evolution of disability in spinocerebellar ataxias (SCAs)
type 1, 2, 3, and 6 (SCA1, 2, 3, 6). Methods We analyzed data of two longitudinal cohorts …