The most significant advance in the medical management of HIV-1 infection has been the
treatment of patients with antiviral drugs, which can suppress HIV-1 replication to …

Since the initial recognition of acquired immunodeficiency syndrome (AIDS) in 1981, an
increased burden of cervical cancer was identified among human immunodeficiency virus …

Background The new protease inhibitors are potent inhibitors of the human
immunodeficiency virus (HIV), and in combination with other antiretroviral drugs they may be …

Background This double-blind study evaluated treatment with either a single nucleoside or
two nucleosides in adults infected with human immunodeficiency virus type 1 (HIV-1) whose …

Highly active antiretroviral therapy (HAART) increases CD4+ cell numbers, but its ability to
correct the human immunodeficiency virus (HIV)–induced immune deficiency remains …

HIV protease plays a crucial role in the viral life cycle and is essential for the generation of
mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its …

Context.—Clinical trials have established the efficacy of antiretroviral therapy with double-
and triple-drug regimens for individuals infected with the human immunodeficiency virus …

ContextUse of antiretroviral drugs, including protease inhibitors, for treatment of human
immunodeficiency virus (HIV) infection has been anecdotally associated with hepatotoxicity …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1
infection. However, limited oral absorption and variable tissue distribution, both of which are …