Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

Deep brain stimulation (DBS) has proven remarkably safe and effective in the treatment of
movement disorders. As a result, it is being increasingly applied to a range of neurologic …

Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …

Secondary generalized seizure (sGS) is a major source of disability in temporal lobe
epilepsy (TLE) with unclear cellular/circuit mechanisms. Here we found that clinical TLE …

Epilepsy, one of the most severe neurological diseases, is characterized by abrupt recurrent
seizures. Despite great progress in the development of antiseizure drugs (ASDs) based on …

Objective Unidentified mechanisms largely restrict the viability of effective therapies in
pharmacoresistant epilepsy. Our previous study revealed that hyperactivity of the subiculum …

Mesial temporal lobe epilepsy (MTLE), the most common form of focal epilepsy in adults, is
often refractory to medication and associated with hippocampal sclerosis. Deep brain …

Objective Drug‐resistant epilepsy causes great clinical danger and still lacks effective
treatments. Methods Here, we used multifaceted approaches combining electrophysiology …

Epilepsy is a circuit-level brain disorder characterized by excessive or hypersynchronous
epileptic seizures involving a complex epileptogenic network. Cumulative evidence …

Epilepsy is a common neurological disorder characterized by hyperexcitability in the brain.
Its pathogenesis is classically associated with an imbalance of excitatory and inhibitory …