Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

BACKGROUND In humans, inadequate trophoblast invasion into the decidua is associated
with the 'great obstetrical syndromes' which include pre-eclampsia, foetal growth restriction …

Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Uterine spiral artery remodeling is required for successful human pregnancy; impaired
remodeling is associated with pregnancy complications, including late miscarriage …

Cell–cell communication is an essential mechanism for the maintenance and development
of various organs, including the female reproductive system. Today, it is well-known that the …

BACKGROUND During pregnancy, maternal uterine spiral arteries (SAs) are remodelled
from minimal-flow, high-resistance vessels into larger diameter vessels with low resistance …

In humans, the placenta provides the only fetomaternal connection and is essential for
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …

STUDY QUESTION Do extravillous trophoblasts (EVTs) invade non-arterial decidual vessels
in healthy and pathological pregnancies? SUMMARY ANSWER Our results reveal that …

Early phases of human pregnancy are associated with the accumulation of a unique subset
of natural killer (NK) cells in the maternal decidua. Decidual NK (dNK) cells that are devoid …