Brain edema is a potentially fatal pathological state that occurs after brain injuries such as
stroke and head trauma. In the edematous brain, excess accumulation of extracellular fluid …

Matrix metalloproteinases are versatile endopeptidases with many different functions in the
body in health and disease. In the brain, matrix metalloproteinases are critical for tissue …

Aberrant neovascularization contributes to diseases such as cancer, blindness and
atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although …

The blood-brain barrier (BBB) is the regulated interface between the peripheral circulation
and the central nervous system (CNS). Although originally observed by Paul Ehrlich in 1885 …

Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to
many neurological disorders, including stroke and Alzheimer's disease. How the basement …

Establishment of a human model of the blood‐brain barrier has proven to be a difficult goal.
To accomplish this, normal human brain endothelial cells were transduced by lentiviral …

Retinal vascular disease has the potential to affect hundreds of millions of people, with the
inherent risk of vision loss related to cystoid macular edema. Although there have been …

The blood-brain barrier (BBB) is a highly specialized structural and biochemical barrier that
regulates the entry of blood-borne molecules into brain, and preserves ionic homeostasis …

The specifically regulated restrictive permeability barrier to cells and molecules is the most
important feature of the blood–brain barrier (BBB). The aim of this review was to summarize …

Major depression represents a complex and prevalent psychological disease that is
characterized by persistent depressed mood, impaired cognitive function and complicated …