Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

B Lu, L Wei, G Shi, J Du - Advanced Science, 2024 - Wiley Online Library
Current management of anesthesia‐associated complications falls short in terms of both
efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio …

Investigation of monoclonal antibody CSX-1004 for fentanyl overdose

PT Bremer, EL Burke, AC Barrett, RI Desai - Nature Communications, 2023 - nature.com
The opioid crisis in the United States is primarily driven by the highly potent synthetic opioid
fentanyl leading to> 70,000 overdose deaths annually; thus, new therapies for fentanyl …

Identification and biophysical characterization of a novel domain-swapped camelid antibody specific for fentanyl

JP Gallant, D Hicks, K Shi, NH Moeller, B Hoppe… - Journal of Biological …, 2024 - jbc.org
Opioid use disorders (OUD) and overdoses are ever-evolving public health threats that
continue to grow in incidence and prevalence in the United States and abroad. Current …

Development of fentanyl-specific monoclonal antibody (mAb) to antagonize the pharmacological effects of fentanyl

XY Chen, L Wang, X Ma, F Yang, X Wang, P Xu… - Toxicology and Applied …, 2024 - Elsevier
Fentanyl, a critical component of opioid analgesics, poses a severe threat to public health,
exacerbating the drug problem due to its potential fatality. Herein, we present two novel …

[HTML][HTML] The fentanyl-specific antibody FenAb024 can shield against carfentanil effects

K Urban, A Gkeka, M Chandra, D Greiner, S Pollich… - Toxicology Letters, 2024 - Elsevier
The surge in opioid-related deaths, driven predominantly by fentanyl and its synthetic
derivatives, has become a critical public health concern, which is particularly evident in the …