Homeostasis is a prerequisite for health. When homeostasis becomes disrupted, dysfunction
occurs. This is especially the case for the gut microbiota, which under normal conditions …

The organic anion transporters, OAT1 and OAT3, regulate the movement of drugs, toxins,
and endogenous metabolites. In 2006, we proposed that OATs and other SLC22 …

The phenotypic and regulatory variability of drug transporter (DT) are vital for the
understanding of drug responses, drug-drug interactions, multidrug resistances, and so on …

Consumption of fruits and vegetables has been associated with a reduced risk of multiple
diseases, such as metabolic disorders. Flavonols are the most ubiquitous flavonoids in fruits …

Kynurenic acid (KYNA) is an antioxidant degradation product of tryptophan that has been
shown to have a variety of cytoprotective, neuroprotective and neuronal signalling …

The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) are drug
transporters that are expressed in the kidney, with well-established roles in the in vivo …

Patients with end-stage kidney disease (ESKD) suffer from high levels of protein-bound
uremic toxins (PBUTs) that contribute to various comorbidities. Conventional dialysis …

Protein transporters not only have essential functions in regulating the transport of
endogenous substrates and remote communication between organs and organisms, but …

Abstract Organic anion transporter 1 (OAT1/SLC22A6, NKT) is a multispecific drug
transporter in the kidney with numerous substrates, including pharmaceuticals, endogenous …

Human metapneumovirus (HMPV) is an important cause of acute respiratory tract infection
and causes significant morbidity and mortality. There is no specific antiviral drug to treat …