Tuberculosis remains a serious social and public health problem, affecting millions of
people annually. The bacille Calmette-Guerin (BCG) vaccine, used prophylactically, does …

IFN-γ responses to Mycobacterium tuberculosis specific antigens are used as in vitro
diagnostic tests for tuberculosis infection. The tests are sensitive and specific for latent and …

Detection of specific antibodies may represent an additional tool in diagnosis of tuberculosis
(TB). Herein, levels of serum IgG antibodies against early secreted antigenic target (ESAT …

Whole blood based assays, particularly interferon gamma (IFN-γ) release assays (IGRAs),
are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the …

Protection against Mycobacterium tuberculosis infection is dependent on T cell and
macrophage activation regulated by cytokines. Cytokines and chemokines produced at …

INTRODUCTION: The lack of highly-productive Nyssorhynchus darlingi laboratory colonies
limits some studies. We report the first well-established laboratory colony of Ny. darlingi in …

The development of a statistical model based on simple immunological markers which could
predict the response to tuberculosis treatment would facilitate clinical trials of new anti …

Chemokines mediate their biological functions by transmigration of various immune cells to
the site of infection. Tuberculous pleurisy provides an effective model to study the role of …

We evaluated an enzyme-linked immunospot assay for interferon-γ (T SPOT-TB) for rapid
diagnosis of active tuberculosis (TB) in a disease-endemic area. From January to June …

Simultaneous detection of multiple biomarkers might lead to improved diagnostic
performance for Mycobacterium tuberculosis infection. In this study, we screened soluble …