The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin,
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …

Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

GPCRs represent the largest family of integral membrane proteins and were first identified
as receptor proteins that couple via heterotrimeric G‐proteins to regulate a vast variety of …

Calcitonin was discovered over 50 yr ago as a new hormone that rapidly lowers circulating
calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as …

Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery,
filled with therapeutic promise yet fraught with caveats. Allosteric ligands stabilize unique …

It is now recognized that G protein–coupled receptors (GPCRs), once considered largely
independent functional units, have a far more diverse molecular architecture. Receptor …

Our conceptual understanding of the molecular architecture of G-protein coupled receptors
(GPCRs) has transformed over the last decade. Once considered as largely independent …

Adrenomedullin (AM) is a peptide involved both in the pathogenesis of cardiovascular
diseases and in circulatory homeostasis. The high-affinity AM receptor is composed of …

G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …