The microtubule-based motor dynein generates pulling forces for centrosome centration and
mitotic spindle positioning in animal cells. How the essential dynein activator dynactin …

Few techniques are available for studying the nature of forces that drive subcellular
dynamics. Here we develop two complementary ones. The first is femtosecond stereotactic …

In multicellular systems, cells communicate with adjacent cells to determine their positions
and fates, an arrangement important for cellular development. Orientation of cell division …

During asymmetric division of the Caenorhabditis elegans zygote, to properly distribute cell
fate determinants, the mitotic spindle is asymmetrically localized by a combination of …

Asymmetric cell division is one of the fundamental processes to create cell diversity in the
early stage of embryonic development. During this process, the polarity formation in the cell …

Centrosomes serve as a site for microtubule nucleation and these microtubules will grow
and interact with the motor protein dynein at the cortex. The position of the centrosomes …

Starting with Boveri in the 1870s, microscopic investigation of early embryogenesis in a
broad swath of nematode species revealed the central role of asymmetric cell division in …

Few techniques are available for elucidating the nature of forces that drive subcellular
behaviors. Here we develop two complementary ones: 1) femtosecond stereotactic laser …

The centrosomal aster is a mobile and adaptable cellular organelle that exerts and transmits
forces necessary for tasks such as nuclear migration and spindle positioning. Recent …

The centrosomal aster is a mobile and adaptable cellular organelle that exerts and transmits
forces necessary for tasks such as nuclear migration and spindle positioning. Recent …