All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …

Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …

Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

During metastasis, cancer cells disseminate to other parts of the body by entering the
bloodstream in a process that is called intravasation. They then extravasate at metastatic …

Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies
of healing. Here, we investigate the cellular interactions between innate immune cells and …

Sprouting angiogenesis is a dynamic process in which endothelial cells collectively migrate,
shape new lumenized tubes, make new connections, and remodel the nascent network into …

Arteries and veins are specified by antagonistic transcriptional programs. However, during
development and regeneration, new arteries can arise from pre-existing veins through a …

Sprouting angiogenesis requires the coordinated behaviour of endothelial cells, regulated
by Notch and vascular endothelial growth factor receptor (VEGFR) signalling. Here, we use …