Microbiome and Longevity: High Abundance of Longevity-Linked Muribaculaceae in the Gut of the Long-Living Rodent Spalax leucodon

M Sibai, E Altuntaş, B Yıldırım, G Öztürk… - OMICS: A Journal of …, 2020 - liebertpub.com
With a world population living longer as well as marked disparities in life expectancy,
understanding the determinants of longevity is one of the priority research agendas in 21st …

Axolotl: A resourceful vertebrate model for regeneration and beyond

A Bölük, M Yavuz, T Demircan - Developmental Dynamics, 2022 - Wiley Online Library
The regenerative capacity varies significantly among the animal kingdom. Successful
regeneration program in some animals results in the functional restoration of tissues and lost …

The role of the microbiota in regeneration-associated processes

LM Díaz-Díaz, A Rodríguez-Villafañe… - Frontiers in Cell and …, 2022 - frontiersin.org
The microbiota, the set of microorganisms associated with a particular environment or host,
has acquired a prominent role in the study of many physiological and developmental …

A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling …

M Yavuz, LS Takanlou, ÇB Avcı, T Demircan - Gene, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is a major global health problem that often correlates with
poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to …

Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl

M Sibai, E Altuntaş, BE Süzek, B Şahin… - Biochemical and …, 2020 - Elsevier
The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional
regenerative capacity to fully restore an amputated limb throughout the life-long lasting …

The Dynamic Landscapes of Circular RNAs in Axolotl, a Regenerative Medicine Model, with Implications for Early Phase of Limb Regeneration

T Demircan, BE Süzek - OMICS: A Journal of Integrative Biology, 2023 - liebertpub.com
Circular RNAs (circRNAs) are of relevance to regenerative medicine and play crucial roles
in post-transcriptional and translational regulation of biological processes. circRNAs are a …

The effect of hydroquinidine on proliferation and apoptosis of TMZ-sensitive and-resistant GBM Cells

M Yavuz, T Demircan - Anti-Cancer Agents in Medicinal …, 2023 - ingentaconnect.com
Background: Glioblastoma multiforme (GBM) is a lethal form of central nervous system
cancer with a lack of efficient therapy options. Aggressiveness and invasiveness of the GBM …

Characterization of bacterial diversity in wastewater of Indian paper industries with special reference to water quality

I Tyagi, K Tyagi, K Chandra, V Kumar - International Journal of …, 2022 - Springer
The bacterial diversity in terms of structure and community profile, with special reference to
water quality in the wastewater treatment plant of Indian paper industries, is poorly …

Can Microbiome Modulate Regenerative Capacity? A Comparative Microbiome Study Reveals a Dominant Presence of Flavobacteriaceae in Blastema Tissue During …

T Demircan, S Gül, EA Taşçı - OMICS: A Journal of Integrative …, 2024 - liebertpub.com
The axolotl (Ambystoma mexicanum) is renowned for its remarkable regenerative
capabilities, which are not diminished by the transition from a neotenic to a metamorphic …

Temporal microbiome changes in axolotl limb regeneration: Stage‐specific restructuring of bacterial and fungal communities with a Flavobacterium bloom during …

H Altın, B Delice, B Yıldırım… - Wound Repair and …, 2024 - Wiley Online Library
The intricate relationship between regeneration and microbiota has recently gained
attention, spanning diverse model organisms. Axolotl (Ambystoma mexicanum) is a critically …