Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …

The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

Developing therapeutic monoclonal antibodies at pandemic pace | Nature Biotechnology Skip
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Hundreds of therapeutic monoclonal antibodies (mAbs) are currently in development, and
many companies have multiple antibodies in their pipelines. Current methodology used in …

This review describes key milestones related to the production of biopharmaceuticals—
therapies manufactured using recombinant DNA technology. The market for …

The purification of biopharmaceuticals is commonly considered the bottleneck of the
manufacturing process. Increasing product diversity, along with growing regulatory and …

Quality by Design (QbD) is gaining industry acceptance as an approach towards
development and commercialization of biotechnology therapeutic products that are …

Manufacturing of cell culture-derived virus particles for vaccination and gene therapy is a
rapidly growing field in the biopharmaceutical industry. The process involves a number of …

The thermodynamic modeling of protein adsorption on mixed-mode adsorbents
functionalized with ligands carrying both hydrophobic and electrostatic groups was …

Accelerating the scale up of adeno-associated virus (AAV) manufacture is highly desirable
to meet the increased demand for gene therapies. However, the development of …