Oxidative and nitrosative stress in age-related macular degeneration: A review of their role in different stages of disease
C Toma, S De Cillà, A Palumbo, DP Garhwal… - Antioxidants, 2021 - mdpi.com
Although the exact pathogenetic mechanisms leading to age-related macular degeneration
(AMD) have not been clearly identified, oxidative damage in the retina and choroid due to an …
(AMD) have not been clearly identified, oxidative damage in the retina and choroid due to an …
Repeated topical administration of 3 nm cerium oxide nanoparticles reverts disease atrophic phenotype and arrests neovascular degeneration in AMD mouse models
A Badia, A Duarri, A Salas, J Rosell, J Ramis… - ACS …, 2023 - ACS Publications
Increased oxidative stress in the retina and retinal pigment epithelium is implicated in age-
related macular degeneration (AMD). Antioxidant cerium oxide nanoparticles (CeO2NPs) …
related macular degeneration (AMD). Antioxidant cerium oxide nanoparticles (CeO2NPs) …
Recent advances of exosomes in age-related macular degeneration
F Gu, J Jiang, P Sun - Frontiers in Pharmacology, 2023 - frontiersin.org
Exosomes are 30–150 nm extracellular vesicles that are secreted by almost all types of
cells. Exosomes contain a variety of biologically active substances, such as proteins, nucleic …
cells. Exosomes contain a variety of biologically active substances, such as proteins, nucleic …
Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages
H Isla-Magrané, A Veiga, J García-Arumí… - Stem cell research & …, 2021 - Springer
Background Recently, great efforts have been made to design protocols for obtaining ocular
cells from human stem cells to model diseases or for regenerative purposes. Current …
cells from human stem cells to model diseases or for regenerative purposes. Current …
[HTML][HTML] Repopulation of decellularized retinas with hiPSC-derived retinal pigment epithelial and ocular progenitor cells shows cell engraftment, organization and …
M Maqueda, JL Mosquera, J García-Arumí, A Veiga… - Biomaterials, 2021 - Elsevier
The retinal extracellular matrix (ECM) provides architectural support, adhesion and signal
guidance that controls retinal development. Decellularization of the ECM affords great …
guidance that controls retinal development. Decellularization of the ECM affords great …
Neovascular progression and retinal dysfunction in the laser-induced choroidal neovascularization mouse model
The mouse model of laser-induced choroidal neovascularization (LI-CNV) has been widely
used to study neovascular age-related macular degeneration; however, it still lacks a …
used to study neovascular age-related macular degeneration; however, it still lacks a …
Transplantation of human induced pluripotent stem cell-derived retinal pigment epithelium in a swine model of geographic atrophy
A Duarri, E Rodríguez-Bocanegra… - International journal of …, 2021 - mdpi.com
Background: The aim of this study was to test the feasibility and safety of subretinal
transplantation of human induced pluripotent stem cell (hiPSC)-derived retinal pigment …
transplantation of human induced pluripotent stem cell (hiPSC)-derived retinal pigment …
Voluntary exercise preserves visual function and reduces inflammatory response in an adult mouse model of autosomal dominant retinitis pigmentosa
Whole-body physical exercise has been shown to promote retinal structure and function
preservation in animal models of retinal degeneration. It is currently unknown how exercise …
preservation in animal models of retinal degeneration. It is currently unknown how exercise …
All-trans retinoic acid modulates pigmentation, neuroretinal maturation, and corneal transparency in human multiocular organoids
H Isla-Magrané, M Zufiaurre-Seijo… - Stem Cell Research & …, 2022 - Springer
Background All-trans retinoic acid (ATRA) plays an essential role during human eye
development, being temporally and spatially adjusted to create gradient concentrations that …
development, being temporally and spatially adjusted to create gradient concentrations that …
Relationship between CCL2 gene 2518A/G (rs1024611) polymorphism and age-related macular degeneration susceptibility: meta-analysis and trial sequential …
H Tian, W Xu, L Wen, T Song, Y Tian, L Tang… - International …, 2024 - Springer
Purpose This study aimed to investigate the association between the CC-cytokine ligand-2
(CCL2) 2518A/G (rs1024611) single nucleotide polymorphism (SNP) and susceptibility to …
(CCL2) 2518A/G (rs1024611) single nucleotide polymorphism (SNP) and susceptibility to …