Sounding the alarmins—the role of alarmin cytokines in asthma

GM Gauvreau, C Bergeron, LP Boulet, DW Cockcroft… - Allergy, 2023 - Wiley Online Library
The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25
are epithelial cell‐derived mediators that contribute to the pathobiology and …

Diagnostic value of sST2 in cardiovascular diseases: a systematic review and meta-analysis

T Zhang, C Xu, R Zhao, Z Cao - Frontiers in cardiovascular medicine, 2021 - frontiersin.org
Biomarkers such as B-type natriuretic peptide (BNP), N-terminal pro-BNP (NT-proBNP),
cardiac troponin (cTn), and CK-MB contribute significantly to the diagnosis of cardiovascular …

[HTML][HTML] Sex/gender-related differences in inflammaging

F Olivieri, F Marchegiani, G Matacchione… - Mechanisms of ageing …, 2023 - Elsevier
Geroscience puts mechanisms of aging as a driver of the most common age-related
diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of …

Signaling pathways and potential therapeutic strategies in cardiac fibrosis

A Bertaud, A Joshkon, X Heim, R Bachelier… - International Journal of …, 2023 - mdpi.com
Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of
different acute (myocardial infarction) or chronic (diabetes, hypertension,…) diseases but …

Exploring the complex relationship between diabetes and cardiovascular complications: understanding diabetic cardiomyopathy and promising therapies

N Ghosh, L Chacko, H Bhattacharya, J Vallamkondu… - Biomedicines, 2023 - mdpi.com
Diabetes mellitus (DM) and cardiovascular complications are two unmet medical
emergencies that can occur together. The rising incidence of heart failure in diabetic …

Soluble ST2 in coronary artery disease: Clinical biomarkers and treatment guidance

J Zhang, Z Chen, M Ma, Y He - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
The IL-33/ST2 L signaling pathway is involved in the pathophysiological processes of
several diseases and mainly exerts anti-inflammatory and antifibrotic effects. Soluble …

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease

Y Jiang, X Zhou, HY Wong, L Ouyang, FCF Ip… - Nature aging, 2022 - nature.com
Abstract Changes in the levels of circulating proteins are associated with Alzheimer's
disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble …

Novel biomarkers and their role in the diagnosis and prognosis of acute coronary syndrome

M Katsioupa, I Kourampi, E Oikonomou, V Tsigkou… - Life, 2023 - mdpi.com
The burden of cardiovascular diseases and the critical role of acute coronary syndrome
(ACS) in their progression underscore the need for effective diagnostic and prognostic tools …

[HTML][HTML] Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases

P He, M Wu, L Zheng, Y Duan, Q Fan, X Zhu… - Cytokine & Growth Factor …, 2024 - Elsevier
Abstract Interleukin (IL)− 33, a nuclear factor and pleiotropic cytokine of the IL-1 family, is
gaining attention owing to its important role in chronic inflammatory and autoimmune …

Soluble ST2 in Heart failure: a clinical role beyond B-Type natriuretic peptide

M Riccardi, PL Myhre, TA Zelniker, M Metra… - Journal of …, 2023 - mdpi.com
Soluble (s) ST2 has been proposed as a useful biomarker for heart failure (HF) patient
management. Myocardial damage or mechanical stress stimulate sST2 release. ST2 …