This review summarizes the advancements in rhodium-catalyzed asymmetric C–H
functionalization reactions during the last two decades. Parallel to the rapidly developed …

The development of new methods for the direct functionalization of unactivated C–H bonds
is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic …

This Review summarizes the advances in the construction of all-carbon quaternary
stereocenters via catalytic enantioselective desymmetrization of prochiral and meso …

Quaternary carbon stereocentres—carbon atoms to which four distinct carbon substituents
are attached—are common features of molecules found in nature. However, before recent …

Design of ligands in transition-metal catalyzed reactions is challenging, especially in
asymmetric transformations. With each step in the catalytic cycle promoted by its privileged …

Inspired by the need for green and sustainable chemistry,(1) synthetic chemists seek more
efficient ways to construct carbon− carbon (C− C) bonds, the essential link in all organic …

Cyclopropanes are structural motifs that are widely present in natural products and bioactive
molecules, and they are also tremendously useful building blocks in synthetic organic …

In addition to the appealing synthetic transformations that cyclopropanes present, they are
also part of larger molecular structures that possess a wide range of biological properties …

Chiral N-cyclopropyl pyrazoles and structurally related heterocycles are prepared using an
earth-abundant copper catalyst under mild reaction conditions with high regio-, diastereo …

Conspectus One of the major challenges facing organic synthesis in the 21st century is the
utilization of abundantly available feedstock chemicals for fine chemical synthesis. Regio …