Environmental determinants of cardiovascular disease

A Bhatnagar - Circulation research, 2017 - Am Heart Assoc
Many features of the environment have been found to exert an important influence on
cardiovascular disease (CVD) risk, progression, and severity. Changes in the environment …

Resveratrol and vascular function

H Li, N Xia, S Hasselwander, A Daiber - International journal of molecular …, 2019 - mdpi.com
Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating
the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and …

Obesity and COVID-19: molecular mechanisms linking both pandemics

A Ritter, NN Kreis, F Louwen, J Yuan - International journal of molecular …, 2020 - mdpi.com
The coronavirus disease 2019 COVID-19 pandemic is rapidly spreading worldwide and is
becoming a major public health crisis. Increasing evidence demonstrates a strong …

Hemostasis, endothelial stress, inflammation, and the metabolic syndrome

G Grandl, C Wolfrum - Seminars in immunopathology, 2018 - Springer
Obesity and the metabolic syndrome (MS) are two of the pressing healthcare problems of
our time. The MS is defined as increased abdominal obesity in concert with elevated fasting …

Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue

SN Saxton, BJ Clark, SB Withers… - Physiological …, 2019 - journals.physiology.org
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

[HTML][HTML] Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

R Divella, R De Luca, I Abbate, E Naglieri… - Journal of …, 2016 - ncbi.nlm.nih.gov
Adipose tissue in addition to its ability to keep lipids is now recognized as a real organ with
both metabolic and endocrine functions. Recent studies demonstrated that in obese animals …

Endothelial dysfunction in obesity

A Engin - Obesity and lipotoxicity, 2017 - Springer
Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

JK Salabei, AA Gibb, BG Hill - Nature protocols, 2014 - nature.com
Extracellular flux (XF) analysis has become a mainstream method for measuring
mitochondrial function in cells and tissues. Although this technique is commonly used to …

[HTML][HTML] Regulation of obesity and insulin resistance by nitric oxide

BE Sansbury, BG Hill - Free radical biology and medicine, 2014 - Elsevier
Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has
quickly become a worldwide pandemic with few tangible and safe treatment options …

Obesity and atherosclerosis: mechanistic insights

F Lovren, H Teoh, S Verma - Canadian Journal of Cardiology, 2015 - Elsevier
Obesity is a multifactorial chronic disease characterized by an accumulation of visceral and
subcutaneous fat, which leads to a predisposition toward cardiometabolic diseases. A …