Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other …

In the recent years, there have been an increasing number of reports on favourable effects of
statins in patients with advanced chronic liver disease. These include reduction in portal …

Background Simvastatin exerts pleiotropic effects on cardiovascular system. However, its
effect on non-alcoholic fatty liver disease, especially the liver fibrosis, remains obscure. We …

Background & Aims The transcription factor Krüppel-like factor 2 (KLF2), inducible by
simvastatin, confers endothelial vasoprotection. Considering recent data suggesting …

Background Statin has been more and more widely used in chronic liver disease, however,
existed studies have attained contradictory results. According to the present study, we aimed …

Background: Simvastatin is a cholesterol‐lowering drug whose pleiotropic effects may have
a therapeutic impact on bone. This study evaluates the effect of simvastatin on rats subjected …

Microglial activation has been widely demonstrated to mediate inflammatory processes that
are crucial in several neurodegenerative disorders. Pharmaceuticals that can deliver direct …

Increased reactive oxidative stress, lipid peroxidation, inflammation, and fibrosis, which
contribute to tissue damage and development and progression of nonalcoholic liver disease …

Impairment of endothelial nitric oxide synthase (eNOS) activity is implicated in the
pathogenesis of endothelial dysfunction in many diseases including ischaemic stroke. The …

Many studies have elucidated the protective associations of statin use with liver cancer or
mortality, but studies examining statin's effect on the risk of progression to liver cirrhosis …