The ubiquitin–proteasome pathway of protein degradation is one of the major mechanisms
that are involved in the maintenance of the proper levels of cellular proteins. The regulation …

Mercury (Hg) exposure remains a major public health concern due to its widespread
distribution in the environment. Organic mercurials, such as MeHg, have been extensively …

Rad23 is an adaptor protein that binds to both ubiquitinated substrates and to the
proteasome. Despite its association with the proteasome, Rad23 escapes degradation. Here …

Stress conditions can cause the relocalization of proteasomes to condensates in yeast and
mammalian cells. The interactions that facilitate the formation of proteasome condensates …

Alzheimer disease (AD) is associated with extracellular deposition of proteolytic fragments of
amyloid precursor protein (APP). Although mutations in APP and proteases that mediate its …

A moonlighting protein is one, which carries out multiple, often wholly unrelated, functions.
The RAD23 protein is a fascinating example of this, where the same polypeptide and the …

Environmental and occupational exposures to heavy metals such as methylmercury (MeHg)
and cadmium (Cd) pose significant health risks to humans, including neurotoxicity. The …

Background Mercury is a ubiquitous environmental toxicant that exists in multiple chemical
forms. A paucity of information exists regarding the differences or similarities by which …

Toxic protein aggregates are key features of progressive neurodegenerative diseases. In
addition to “seed” proteins diagnostic for each neuropathy (eg, Aβ1–42 and tau in …

Single nucleotide polymorphisms in the ubiquilin-1 gene may confer risk for late-onset
Alzheimer disease (AD). We have shown previously that ubiquilin-1 functions as a molecular …