Abstract Information and function of a genome are not only decorated with epigenetic marks
in the linear DNA sequence but also in their non-random spatial organization in the nucleus …

The genome of a eukaryotic organism is comprised of a supra-molecular complex of
chromatin fibers and intricately folded three-dimensional (3D) structures. Chromosomal …

Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

Background The nuclear envelope not only serves as a physical barrier separating nuclear
content from the cytoplasm but also plays critical roles in modulating the three-dimensional …

Guanylate binding proteins (GBPs) are prominent regulators of immunity not known to be
required for nuclear envelope formation and morphogenesis. Here we identify the …

Chromatin is not a uniform macromolecular entity; it contains different domains
characterized by complex signatures of DNA and histone modifications. Such domains are …

Eukaryotic genomes are highly folded for packing into higher‐order chromatin structures in
the nucleus. With the emergence of state‐of‐the‐art chromosome conformation capture …

Genomic architecture facilitates chromosome recognition, pairing, and recombination.
Telomeres and subtelomeres play an important role at the beginning of meiosis in specific …

Spatial organization of chromatin contributes to gene regulation of many cellular processes
and includes a connection of chromatin with the nuclear lamina (NL). The NL is a protein …

The four main types of biomolecules are nucleic acids, proteins, carbohydrates and lipids.
The knowledge about their respective interactions is as important as the individual …