Lipoprotein‐associated phospholipase A2: the story continues

F Huang, K Wang, J Shen - Medicinal research reviews, 2020 - Wiley Online Library
Inflammation is thought to play an important role in the pathogenesis of vascular diseases.
Lipoprotein‐associated phospholipase A2 (Lp‐PLA2) mediates vascular inflammation …

Diabetic retinopathy: Involved cells, biomarkers, and treatments

J Ren, S Zhang, Y Pan, M Jin, J Li, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …

Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population

AL Rajendrakumar, SM Hapca, ATN Nair, Y Huang… - BMC medicine, 2023 - Springer
Background Diabetic retinopathy (DR) is a major sight-threatening microvascular
complication in individuals with diabetes. Systemic inflammation combined with oxidative …

Lp-PLA2, a new biomarker of vascular disorders in metabolic diseases

A De Stefano, L Mannucci, F Tamburi… - International …, 2019 - journals.sagepub.com
Metabolic diseases are chronic disorders correlated to a greater risk of cardiovascular event
and death. Recently, many data have sustained the biological link between microvascular …

Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation

S Lv, Z Zeng, W Gan, W Wang, T Li, Y Hou… - Acta Pharmacologica …, 2021 - nature.com
Macrophage-mediated inflammation plays an important role in hypertensive cardiac
remodeling, whereas effective pharmacological treatments targeting cardiac inflammation …

The design and discovery of phospholipase A2 inhibitors for the treatment of inflammatory diseases

CS Batsika, ADD Gerogiannopoulou… - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Phospholipase A2 (PLA2) enzymes are implicated in several pathological
conditions such as arthritis, cardiovascular diseases, and diabetes. It is highly important to …

The diagnostic value of lipoprotein-associated phospholipase A2 in early diabetic nephropathy

Y Zhai, X Cao, S Liu, Y Shen - Annals of Medicine, 2023 - Taylor & Francis
Objective The aim of this study was to investigate diagnosis of lipoprotein-associated
phospholipase A2 (Lp-PLA2) in early diabetic nephropathy (DN). Methods A total of 342 …

Diagnostic circulating biomarkers to detect vision‐threatening diabetic retinopathy: Potential screening tool of the future?

K Frudd, S Sivaprasad, R Raman… - Acta …, 2022 - Wiley Online Library
With the increasing prevalence of diabetes in developing and developed countries, the
socio‐economic burden of diabetic retinopathy (DR), the leading complication of diabetes, is …

Using data to improve the management of diabetes: The Tayside experience

MK Siddiqui, C Hall, SG Cunningham… - Diabetes …, 2022 - Am Diabetes Assoc
Tayside is a region in the East of Scotland and forms one of nine local government regions
in the country. It is home to approximately 416,000 individuals who fall under the National …

Assessing stroke recurrence risk by using a lipoprotein-associated phospholipase A2 and platelet count-based nomogram

Y Zhou, Y Feng, N Xin, J Lu, X Xu - Molecular Neurobiology, 2024 - Springer
Stroke recurrence remains a critical challenge in clinical neurology, necessitating the
identification of reliable predictive markers for better management and treatment strategies …