Mouse models of atherosclerosis in translational research
Atherosclerotic cardiovascular disease (CVD), the major cause of premature human
mortality, is a chronic and progressive metabolic and inflammatory disease in large-and …
mortality, is a chronic and progressive metabolic and inflammatory disease in large-and …
Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology
W Liang, AL Menke, A Driessen, GH Koek… - PloS one, 2014 - journals.plos.org
Background and aims The recently developed histological scoring system for non-alcoholic
fatty liver disease (NAFLD) by the NASH Clinical Research Network (NASH-CRN) has been …
fatty liver disease (NAFLD) by the NASH Clinical Research Network (NASH-CRN) has been …
The emerging landscape of peptide-based inhibitors of PCSK9
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a clinically validated target for
treating cardiovascular disease (CVD) due to its involvement in cholesterol metabolism …
treating cardiovascular disease (CVD) due to its involvement in cholesterol metabolism …
Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit
Objective Butyrate exerts metabolic benefits in mice and humans, the underlying
mechanisms being still unclear. We aimed to investigate the effect of butyrate on appetite …
mechanisms being still unclear. We aimed to investigate the effect of butyrate on appetite …
VEGFB/VEGFR1-induced expansion of adipose vasculature counteracts obesity and related metabolic complications
Impaired angiogenesis has been implicated in adipose tissue dysfunction and the
development of obesity and associated metabolic disorders. Here, we report the unexpected …
development of obesity and associated metabolic disorders. Here, we report the unexpected …
FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
C Liu, M Schönke, B Spoorenberg, JM Lambooij… - Elife, 2023 - elifesciences.org
Analogues of the hepatokine fibroblast growth factor 21 (FGF21) are in clinical development
for type 2 diabetes and nonalcoholic steatohepatitis (NASH) treatment. Although their …
for type 2 diabetes and nonalcoholic steatohepatitis (NASH) treatment. Although their …
Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
Aims Fibroblast growth factor (FGF) 21, a key regulator of energy metabolism, is currently
evaluated in humans for treatment of type 2 diabetes and non-alcoholic steatohepatitis …
evaluated in humans for treatment of type 2 diabetes and non-alcoholic steatohepatitis …
[HTML][HTML] Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4
Short-chain fatty acids, including butyrate, have multiple metabolic benefits in individuals
who are lean but not in individuals with metabolic syndrome, with the underlying …
who are lean but not in individuals with metabolic syndrome, with the underlying …
Akkermansia muciniphila Exerts Lipid‐Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3‐Leiden.CETP Mice
S Katiraei, MR de Vries, AH Costain… - Molecular nutrition & …, 2020 - Wiley Online Library
Scope Akkermansia muciniphila (A. muciniphila) is an intestinal commensal with anti‐
inflammatory properties both in the intestine and other organs. The aim is to investigate the …
inflammatory properties both in the intestine and other organs. The aim is to investigate the …
In vivo magnetic resonance imaging‐based detection of heterogeneous endothelial response in thoracic and abdominal aorta to short‐term high‐fat diet ascribed to …
A Bar, A Kieronska‐Rudek, B Proniewski… - Journal of the …, 2020 - Am Heart Assoc
Background Long‐term feeding with a high‐fat diet (HFD) induces endothelial dysfunction in
mice, but early HFD‐induced effects on endothelium have not been well characterized …
mice, but early HFD‐induced effects on endothelium have not been well characterized …