Progress and impact of Latin American natural product databases
A Gómez-García, JL Medina-Franco - Biomolecules, 2022 - mdpi.com
Natural products (NPs) are a rich source of structurally novel molecules, and the chemical
space they encompass is far from being fully explored. Over history, NPs have represented a …
space they encompass is far from being fully explored. Over history, NPs have represented a …
IMPPAT 2.0: An enhanced and expanded phytochemical atlas of Indian medicinal plants
Compilation, curation, digitization, and exploration of the phytochemical space of Indian
medicinal plants can expedite ongoing efforts toward natural product and traditional …
medicinal plants can expedite ongoing efforts toward natural product and traditional …
Potential phytochemical inhibitors of SARS-CoV-2 helicase Nsp13: A molecular docking and dynamic simulation study
RP Vivek-Ananth, S Krishnaswamy, A Samal - Molecular diversity, 2022 - Springer
Abstract The SARS-CoV-2 helicase Nsp13 is a promising target for developing anti-COVID
drugs. In the present study, we have identified potential natural product inhibitors of SARS …
drugs. In the present study, we have identified potential natural product inhibitors of SARS …
Discovery of novel CDK4/6 inhibitors from fungal secondary metabolites
A Debnath, R Mazumder, RK Singh… - International Journal of …, 2024 - Elsevier
The development of targeted therapies for breast cancer, particularly those focusing on
cyclin-dependent kinases 4/6 (CDK4/6), has significantly improved patient outcomes …
cyclin-dependent kinases 4/6 (CDK4/6), has significantly improved patient outcomes …
Sterenin M as a potential inhibitor of SARS-CoV-2 main protease identified from MeFSAT database using molecular docking, molecular dynamics simulation and …
The disease outbreak of Coronavirus disease-19 (COVID-19), caused by the novel SARS-
CoV-2 virus, remains a public health concern. COVID-19 is spreading rapidly with a high …
CoV-2 virus, remains a public health concern. COVID-19 is spreading rapidly with a high …
The Cytotoxic Properties of Extreme Fungi's Bioactive Components—An Updated Metabolic and Omics Overview
Fungi are the most diverse living organisms on planet Earth, where their ubiquitous
presence in various ecosystems offers vast potential for the research and discovery of new …
presence in various ecosystems offers vast potential for the research and discovery of new …
Predicting fungal secondary metabolite activity from biosynthetic gene cluster data using machine learning
Fungal secondary metabolites (SMs) contribute to the diversity of fungal ecological
communities, niches, and lifestyles. Many fungal SMs have one or more medically and …
communities, niches, and lifestyles. Many fungal SMs have one or more medically and …
[HTML][HTML] Molecular docking and dynamics simulation study of medicinal fungi derived secondary metabolites as potential inhibitor for COVID-19 treatment
The severity of COVID-19, lack of specific treatment, and controversies on the vaccine's
efficacy demand the development of new drugs against SARS-CoV-2. Fungi produce …
efficacy demand the development of new drugs against SARS-CoV-2. Fungi produce …
Metabolomic profiling, nutritional parameters and potential bioactive metabolites of the edible mushroom Tricholoma mesoamericanum
R Gamboa-Becerra, L Montoya… - … Journal of Food …, 2024 - academic.oup.com
Edible Mushrooms boast a diverse array of biomolecules with exceptional nutritional and
bioactive benefits for humans. This study conducted metabolomic and nutritional analyses …
bioactive benefits for humans. This study conducted metabolomic and nutritional analyses …
Integrated machine learning and chemoinformatics-based screening of mycotic compounds against kinesin spindle proteinEg5 for lung cancer therapy
Among the various types of cancer, lung cancer is the second most-diagnosed cancer
worldwide. The kinesin spindle protein, Eg5, is a vital protein behind bipolar mitotic spindle …
worldwide. The kinesin spindle protein, Eg5, is a vital protein behind bipolar mitotic spindle …