Leading biological hypotheses propose that biological changes may underlie major
depressive disorder onset and relapse/recurrence. Here, we investigate if there is …

The innate immune system is dysregulated in depression; however, less is known about the
longitudinal associations of depression and inflammatory biomarkers. We investigated the …

Importance It is unclear whether differences exist in the magnitude and variability of pro-
inflammatory mediators in the different phases of bipolar disorder (BD) and among subjects …

Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

Background While cross-sectional associations of inflammatory markers interleukin-6 (IL-6)
and C-reactive protein with major depressive disorder are well established, evidence for …

Importance Schizophrenia and major depressive disorder (MDD) are associated with
increased risks of immunologic disease and metabolic syndrome. It is unclear to what extent …

Background Major depressive disorder (MDD) is linked to higher cardio-metabolic
comorbidity that may in part be due to the low-grade inflammation and poorer metabolic …

Abstract Major Depressive Disorder (MDD) is a heterogeneous disorder that affects twice as
many women than men. Precluding advances in more tailored and efficacious treatments for …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Background Concentrations of C-reactive protein (CRP), interleukin 6 (IL-6) and other
inflammatory markers are elevated in people with depression and anxiety compared to …