The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …

Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose
metabolism. This metabolite has been implicated in diabetic complications as it is a strong …

Non-enzymatic posttranslational modifications are believed to affect at least 30% of human
proteins, commonly termed glycation. Many of these modifications are implicated in various …

Glucose and fructose metabolism originates the highly reactive byproduct methylglyoxal
(MG), which is a strong precursor of advanced glycation end products (AGE). The MG has …

The early stages of antibiotic development include the identification of novel hit compounds.
Since actinomycetes and myxobacteria are still the most important natural sources of active …

Elevated oxidized stress contributes to lens cataracts, and gap junctions play important roles
in maintaining lens transparency. As well as forming gap junctions, connexin (Cx) proteins …

Lens proteins become increasingly cross-linked through nondisulfide linkages during aging
and cataract formation. One mechanism that has been implicated in this cross-linking is …

Abstract α-crystallin is a structurally essential small heat shock protein (sHSP) with a
chaperone-like activity which maintains transparency of the lenticular tissues during a period …

Background The findings that α-crystallins are multi-functional proteins with diverse
biological functions have generated considerable interest in understanding their role in …