The steroid hormone aldosterone regulates sodium and potassium homeostasis.
Aldosterone and activation of the mineralocorticoid receptor also causes inflammation and …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

Diabetes mellitus is known to trigger retinopathy, neuropathy and nephropathy. Diabetic
nephropathy, a long-term major microvascular complication of uncontrolled hyperglycemia …

Direct deleterious effects of aldosterone in the heart include development of myocardial
hypertrophy, ventricular remodeling, proarrhythmogenic effects, myocardial ischemia …

Aldosterone, a steroid hormone with mineralocorticoid activity, is mainly recognized for its
action on sodium reabsorption in the distal nephron of the kidney, which is mediated by the …

The existence of local or tissue-based renin-angiotensin-aldosterone systems (RAAS) is
well documented and has been implicated as a key player in the pathogenesis of …

The mechanisms that drive the development of diabetic nephropathy remain undetermined.
Only 30–40% of patients with diabetes mellitus develop overt nephropathy, which suggests …

In the last decade significant progress has been made in the understanding of
mineralocorticoid receptor (MR) function and its implications for physiology and disease …

Diabetic kidney disease (DKD) is a major cause of end-stage kidney disease (ESKD)
worldwide. Mineralocorticoid receptor (MR) plays an important role in the development of …

Since the advent of insulin, the improvements in diabetes detection and the therapies to treat
hyperglycemia have reduced the mortality of acute metabolic emergencies, such that today …