Antituberculosis drugs have captured the attention of the scientific community due to the
emergence of drug resistance. Hence, the development of new analogs and new drugs …

Dysfunction of the androgen receptor (AR) signalling axis plays a pivotal role in the
development and progression of prostate cancer (PCa). Steroidal and non-steroidal AR …

In this paper, a novel series of imidazole-based heme oxygenase-1 (HO-1) inhibitors is
reported. These compounds were obtained by modifications of previously described high …

Mannich bases are a class of organic compounds usually obtained by the condensation
reaction between an amine, a compound with active hydrogens, and an aldehyde. They are …

One of the most significant breakthroughs in the battle against tuberculosis is the recent
approval of the quinoline compound, TMC207, for the treatment of drug-resistant …

Background An increased incidence of fungal infections, both invasive and superficial, has
been witnessed over the last two decades. Candida species seem to be the main etiology of …

Mycoses are serious health problem, especially in immunocompromised individuals. A new
imidazole-bearing compound containing an oxime functionality was synthesized and …

Remarkable advances have been made in the development of an environmentally-friendly
approach for the rapid and simple construction of the Active Pharmaceutical Ingredient (API) …

Anti-Candida activities of certain new oximes 4a–d and their respective aromatic esters 5a–l
are reported. The tested compounds 4a–d and 5a–l exhibited better anti-Candida profiles …

Anticonvulsant potential and neurotoxicity of certain new imidazole‐containing
arylsemicarbazones 6a–p are reported. The test compounds 6a–p exhibited anticonvulsant …