Mitochondria are known as the powerhouse of eukaryotic cells. Energy production occurs in
specific dynamic membrane invaginations in the inner mitochondrial membrane called …

Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and
remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL …

Mitochondrial dysfunction contributes to cardiac pathologies. Barriers to new therapies
include an incomplete understanding of underlying molecular culprits and a lack of effective …

Misfolding and aggregate formation by the tau protein has been closely related with
neurotoxicity in a large group of human neurodegenerative disorders, which includes …

Pore-forming proteins (PFPs) are a heterogeneous group of proteins that are expressed and
secreted by a wide range of organisms. PFPs are produced as soluble monomers that bind …

Cardiolipin (CL) is an acidic phospholipid almost exclusively found in the inner
mitochondrial membrane, that not only stabilizes the structure and function of individual …

Exposure to respirable air particulate matter (PM 2.5) in ambient air is associated with
morbidity and premature deaths. A major source of PM 2.5 is the photooxidation of volatile …

Monolysocardiolipin (MLCL) is a three-tailed variant of cardiolipin (CL), the signature lipid of
mitochondria. MLCL is not normally found in healthy tissue but accumulates in mitochondria …

Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature
cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from …

Cardiolipins are phospholipids that are central to proper mitochondrial functioning. Because
mitochondria play crucial roles in differentiation, development, and maturation, we would …