SARS-CoV-2 infection affects different organs and tissues, including the upper and lower
airways, the lung, the gut, the olfactory system and the eye, which may represent one of the …

Most well studied as proteins that restrain the p53 tumor suppressor protein, MDM2 and
MDMX have rich lives outside of their relationship to p53. There is much to learn about how …

Dysfunctional triglyceride‐very low‐density lipoprotein (TG‐VLDL) metabolism is linked to
metabolic‐associated fatty liver disease (MAFLD); however, the underlying cause remains …

Angiogenesis plays a fundamental role in tumor development, as it is crucial for tumor
progression, metastasis development, and invasion. In this view, anti-angiogenic therapy …

Abstract Mouse double minute 2 (MDM2), an E3 ubiquitin ligase and the primary negative
regulator of the tumor suppressor p53, cooperates with its structural homolog MDM4/MDMX …

Lens epithelial cells (LECs) apoptosis induced by oxidative stress is a major factor in age-
related-cataract (ARC) pathogenesis, but there are still many blind nodes in this progress …

Chlamydia (C.) abortus is an emerging zoonotic pathogen. Since data on its antimicrobial
susceptibility are lacking, we aimed to determine minimal inhibitory (MIC) and minimal …

Abstract Die Gattung Chlamydia (C.) umfasst eine Gruppe obligat intrazellulärer Bakterien,
die einen einzigartigen biphasischen Entwicklungszyklus gemeinsam haben. C. abortus gilt …

Murine double minute (MDM)-2 is a cytoplasmic protein well described to counteract the
biological activity of p53 (ie, the central regulator of the cell cycle) in a yingyangelike …

Mutation or loss of p53 is the most common genetic lesion in human cancers, with
simultaneous loss-of-function and gain-of-function pro-oncogenic effects. Because of its …