A fundamental challenge in biology is understanding the molecular details of protein
function. How mutations alter protein activity, regulation, and response to drugs is of critical …

Cancer remains a significant global health challenge, necessitating the exploration of novel
and more precise therapeutic options beyond conventional treatments. In this regard …

Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Despite
advances in treatment, drug resistance remains a critical impediment. Post-translational …

Signaling pathways that drive gene expression are typically depicted as having a dozen or
so landmark phosphorylation and transcriptional events. In reality, thousands of dynamic …

In our previous multicenter study, we delineated the inherent metabolic features of colorectal
cancer (CRC). Therein, we identified a member of the ectonucleotide pyrophosphatase …

The advent of targeted therapies has led to tremendous improvements in treatment options
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …

Background/Aim: Chemotherapy resistance is an important problem in the treatment of
patients with cholangiocarcinoma (CCA) who are not eligible for surgery. This study aimed …

The resistance of colorectal cancer liver metastases (CRLMs) to 5-fluorouracil (5-FU)
chemotherapy remains a significant global health challenge. We investigated the …

Acute myeloid leukemia (AML) is an aggressive blood cancer with a poor prognosis.
Although treatments like allogeneic hematopoietic stem cell transplantation and high-dose …

Base editors enable the direct conversion of target bases without inducing double-strand
breaks, showing great potential for disease modeling and gene therapy. Yet, their …