Major genetic drivers of statin treatment response in African populations and pharmacogenetics of dyslipidemia through a One Health lens
A One Health lens is increasingly significant to address the intertwined challenges in
planetary health concerned with the health of humans, nonhuman animals, plants, and …
planetary health concerned with the health of humans, nonhuman animals, plants, and …
Genetic diversity in drug transporters: impact in African populations
I Rajman, L Knapp, I Hanna - Clinical and translational science, 2020 - Wiley Online Library
Polymorphisms in drug transporters, like the adenosine triposphate‒binding cassette (ABC)
and solute carrier (SLC) superfamilies, may contribute to the observed diversity in drug …
and solute carrier (SLC) superfamilies, may contribute to the observed diversity in drug …
[HTML][HTML] Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations
W Bedada, F de Andrés, E Engidawork, J Hussein… - Scientific reports, 2018 - nature.com
In a one-way cross-over study, we investigated the effect of Khat, a natural amphetamine-
like psychostimulant plant, on catalytic activities of five major drug-metabolizing cytochrome …
like psychostimulant plant, on catalytic activities of five major drug-metabolizing cytochrome …
[HTML][HTML] Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women
RF Mutagonda, AAR Kamuhabwa, OMS Minzi… - Malaria journal, 2017 - Springer
Background Pregnancy has considerable effects on the pharmacokinetic properties of drugs
used to treat uncomplicated Plasmodium falciparum malaria. The role of pharmacogenetic …
used to treat uncomplicated Plasmodium falciparum malaria. The role of pharmacogenetic …
[HTML][HTML] N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians
Background and objectives N-acetyltransferase 2 (NAT2) metabolize several drugs
including isoniazid. We investigated the effect of genotype, geographical difference, and …
including isoniazid. We investigated the effect of genotype, geographical difference, and …
[HTML][HTML] Impact of population and pharmacogenetics variations on efavirenz pharmacokinetics and immunologic outcomes during anti-tuberculosis co-therapy: a …
S Mugusi, A Habtewold, E Ngaimisi… - Frontiers in …, 2020 - frontiersin.org
Efavirenz-based combination antiretroviral-therapy (cART) is the recommended regimen
during tuberculosis (TB) therapy. In a multi-national parallel prospective-cohort study, we …
during tuberculosis (TB) therapy. In a multi-national parallel prospective-cohort study, we …
An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c. 521T> C and ABCG2 c. 421A> C
ND Soko, E Chimusa, C Masimirembwa… - The Pharmacogenomics …, 2019 - nature.com
Abstract Studies in Caucasian and Asian populations consistently associated interindividual
and interethnic variability in rosuvastatin pharmacokinetics to the polymorphisms SLCO1B1 …
and interethnic variability in rosuvastatin pharmacokinetics to the polymorphisms SLCO1B1 …
Development to enable precision medicine in Africa
N Mulder - Personalized Medicine, 2017 - Taylor & Francis
Precision medicine enables the customization of patient care driven by experimental data
and knowledge about an individual or a population. Though the data can include omics data …
and knowledge about an individual or a population. Though the data can include omics data …
Role of pharmacogenetics in rifampicin pharmacokinetics and the potential effect on TB–rifampicin sensitivity among Ugandan patients
Background Suboptimal anti-TB drugs exposure may cause multidrug-resistant TB. The role
of African predominant SLCO1B1 variant alleles on rifampicin pharmacokinetics and the …
of African predominant SLCO1B1 variant alleles on rifampicin pharmacokinetics and the …
Early or deferred initiation of efavirenz during rifampicin‐based TB therapy has no significant effect on CYP3A induction in TB‐HIV infected patients
Background and Purpose In TB‐HIV co‐infection, prompt initiation of TB therapy is
recommended but anti‐retroviral treatment (ART) is often delayed due to potential drug …
recommended but anti‐retroviral treatment (ART) is often delayed due to potential drug …