Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

Mitogen-activated protein kinases (MAPKs) are important for intracellular signal transduction
and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK …

Abstract c-Fos, the protein of the protooncogene c-fos, has been extensively used as a
marker for the activation of nociceptive neurons in the spinal cord for more than twenty years …

Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X
mental retardation protein), a repressor of mRNA translation. According to the metabotropic …

Pain is an essential protective mechanism meant to prevent tissue damages in organisms.
On the other hand, chronic or persistent pain caused, for example, by inflammation or nerve …

GPR55 is activated by l-α-lysophosphatidylinositol (LPI) but also by certain cannabinoids. In
this study, we investigated the GPR55 pharmacology of various cannabinoids, including …

A-type potassium currents are important determinants of neuronal excitability. In spinal cord
dorsal horn neurons, A-type currents are modulated by extracellular signal-regulated …

Plant-based therapies date back centuries. Cannabis sativa is one such plant that was used
medicinally up until the early part of the 20th century. Although rich in diverse and interesting …

Identification of human miRNAs involved in coronavirus-host interplay is important due to the
current COVID-19 pandemic. Therefore, this study aimed to measure the circulating plasma …

Fragile X mental retardation is caused by silencing of the gene (FMR1) that encodes the
RNA-binding protein (FMRP) that influences translation in neurons. A prominent feature of …