For over two decades, the minority stress model has guided research on the health of
sexually-diverse individuals (those who are not exclusively heterosexual) and gender …

The cumulative science linking stress to negative health outcomes is vast. Stress can affect
health directly, through autonomic and neuroendocrine responses, but also indirectly …

Childhood maltreatment is the most important preventable risk factor for psychiatric
disorders. Maltreated individuals typically develop psychiatric disorders at an earlier age …

Stress can influence health throughout the lifespan, yet there is little agreement about what
types and aspects of stress matter most for human health and disease. This is in part …

Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …

Early-life adversity has been associated with a life-long increased risk for psychopathology
and chronic health problems. These long-term negative effects have been explained …

Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …

Objective Childhood maltreatment increases risk for psychopathology. For some highly
prevalent disorders (major depression, substance abuse, anxiety disorders, and …

The developing human brain is shaped by environmental exposures—for better or worse.
Many exposures relevant to mental health are genuinely social in nature or believed to have …