The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Alterations of endothelial cells and the vasculature play a central role in the pathogenesis of
a broad spectrum of the most dreadful of human diseases, as endothelial cells have the key …

High blood pressure is reported in over two-thirds of patients with type 2 diabetes, and its
development coincides with the development of hyperglycaemia. Many pathophysiological …

The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium‐derived …

The endothelium, once considered a mere selectively permeable barrier between the
bloodstream and the outer vascular wall, is now recognized to be a crucial homeostatic …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Background—Essential hypertension is associated with impaired endothelium-dependent
vasodilation. Inactivation of endothelium-derived nitric oxide by oxygen free radicals …

Insulin increases glucose disposal into muscle. In addition, in vivo insulin elicits distinct nitric
oxide synthase-dependent vascular responses to increase total skeletal muscle blood flow …

The endothelium controls vascular tone not only by releasing nitric oxide (NO) and
prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth …

The endothelium is a crucial regulator of vascular physiology, producing in healthy
conditions several substances with a potent antiatherosclerotic properties. Accordingly, the …