Histone dacetylases (HDACs) are a group of enzymes that remove acetyl groups from
histones and regulate expression of tumor suppressor genes. They are implicated in many …

Simple Summary Histopathological classification of endometrial carcinoma has evidenced
two main groups with different biological behavior: low-grade (G1–G2) and high-grade (G3) …

The gold standard text in gynecology is in its Fourteenth Edition, thoroughly revised and
updated and now in full color throughout. Organized into eight sections, this comprehensive …

Estrogens influence many physiological processes in mammals, including but not limited to
reproduction, cardiovascular health, bone integrity, cognition, and behavior. Given this …

The canonical Wnt/β-catenin signaling pathway, an important modulator of progenitor cell
proliferation and differentiation, is highly regulated for the maintenance of critical biological …

Objective: Our objective was to provide a scholarly review of the published literature on
menopausal hormonal therapy (MHT), make scientifically valid assessments of the available …

Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as
microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers …

17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …

Most endometrial carcinomas are diagnosed at an early stage. Still, 15–20% of these
carcinomas recur with limited effect of systemic therapies in metastatic disease. Improved …

OBJECTIVES: Cell lines derived from human ovarian and endometrial cancers, and their
immortalized non-malignant counterparts, are critical tools to investigate and characterize …