[HTML][HTML] Skeletal muscle metabolic alternation develops sarcopenia

Q Yang, P Chan - Aging and Disease, 2022 - ncbi.nlm.nih.gov
Sarcopenia is a new type of senile syndrome with progressive skeletal muscle mass loss
with age, accompanied by decreased muscle strength and/or muscle function. Sarcopenia …

The ties that bind: functional clusters in limb-girdle muscular dystrophy

ER Barton, CA Pacak, WL Stoppel, PB Kang - Skeletal muscle, 2020 - Springer
The limb-girdle muscular dystrophies (LGMDs) are a genetically pleiomorphic class of
inherited muscle diseases that are known to share phenotypic features. Selected LGMD …

Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice

K Nogami, Y Maruyama… - Human molecular …, 2021 - academic.oup.com
Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder characterized by
progressive muscular weakness because of the loss of dystrophin. Extracellular Ca2+ flows …

TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways

Y Zhou, T Tao, G Liu, X Gao, Y Gao, Z Zhuang… - Cell Death & …, 2021 - nature.com
Neuronal apoptosis has an important role in early brain injury (EBI) following subarachnoid
hemorrhage (SAH). TRAF3 was reported as a promising therapeutic target for stroke …

Acute cellular and molecular responses and chronic adaptations to low-load blood flow restriction and high-load resistance exercise in trained individuals

CJ Davids, TC Næss, M Moen… - Journal of applied …, 2021 - journals.physiology.org
Blood flow restriction (BFR) with low-load resistance exercise (RE) is often used as a
surrogate to traditional high-load RE to stimulate muscular adaptations, such as hypertrophy …

LncRNA-FKBP1C regulates muscle fiber type switching by affecting the stability of MYH1B

J Yu, Z Wang, X Yang, M Ma, Z Li, Q Nie - Cell Death Discovery, 2021 - nature.com
Long non-coding RNAs (lncRNAs) are well-known to participate in a variety of important
regulatory processes in myogenesis. In our previous RNA-seq study (accession number …

The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy

FA Graca, M Rai, LC Hunt, A Stephan, YD Wang… - Nature …, 2022 - nature.com
Decline in skeletal muscle cell size (myofiber atrophy) is a key feature of cancer-induced
wasting (cachexia). In particular, atrophy of the diaphragm, the major muscle responsible for …

[HTML][HTML] Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy

BL Lin, JY Shin, WPD Jeffreys, N Wang, CA Lukban… - JCI insight, 2022 - ncbi.nlm.nih.gov
Gene mutations causing loss of dystrophin result in the severe muscle disease known as
Duchenne muscular dystrophy (DMD). Despite efforts at genetic repair, DMD therapy …

Subcutaneous and intramuscular fat transcriptomes show large differences in network organization and associations with adipose traits in pigs

Y Zhang, Y Sun, Z Wu, X Xiong, J Zhang, J Ma… - Science China Life …, 2021 - Springer
Subcutaneous fat (SCF) and intramuscular fat (IMF) deposition is relevant to health in
humans, as well as meat production and quality in pigs. In this study, we generated RNA …

Potential effects of resistant exercise on cognitive and muscle functions mediated by myokines in sarcopenic obese mice

G Lim, H Lee, Y Lim - Biomedicines, 2022 - mdpi.com
Recently, it has been demonstrated that in sarcopenic obesity (SO), physical activity could
improve cognitive functions. Moreover, previous studies suggested that muscle contraction …