Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Acidic metabolic waste products accumulate in the tumor microenvironment because of high
metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and …

Cancer tissues are composed of cancer cells and the surrounding stromal cells (eg,
fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular …

It is established that the interaction between microenvironment and cancer cells has a
critical role in tumor development, given the dependence of neoplastic cells on stromal …

The tumor suppressor p53 has established functions in cancer. Specifically, it has been
shown to cause cell-cycle arrest and apoptosis in response to DNA damage. It is also one of …

A distinctive feature of cancer cells of various origins involves alterations of the composition
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …

Breast cancer has been shown to live in the tumor microenvironment, which consists of not
only breast cancer cells themselves but also a significant amount of pathophysiologically …

Metabolic homeostasis of fatty acids is complex and well-regulated in all organisms. The
biosynthesis of saturated fatty acids (SFA) in mammals provides substrates for β-oxidation …

Breast cancer is the leading cause of cancer death among women worldwide. Accumulating
evidence indicates that the local recurrent and/or distant metastatic tumors, the major causes …

Simple Summary In the last 20 years, the tumor microenvironment (TME) has raised an
increasing interest from the therapeutic point of view. Indeed, different strategies targeting …