Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular
components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes …

Background: Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower
organisms. TRE exhibits an extraordinary ability to protect cells against different kinds of …

Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer's
Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In …

Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Lysosomes figure prominently in theories of aging as the proteolytic system most
responsible for eliminating growing burdens of damaged proteins and organelles in aging …

Key points In a cold environment, mammals increase their food intake while fish decrease or
stop feeding. However, the physiological value of fasting during cold resistance in fish is …

Duchenne muscular dystrophy (DMD) is a fatal degenerative muscle disease resulting from
mutations in the dystrophin gene. Increased oxidative stress and altered Ca2+ homeostasis …

Macroautophagy/autophagy is a key catabolic process, essential for maintaining cellular
homeostasis and survival through the removal and recycling of unwanted cellular material …

Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness
worldwide. Increasing evidence suggests oxidative damage and immune response defects …