Deep-brain optical recording of neural dynamics during behavior

ZC Zhou, A Gordon-Fennell, SC Piantadosi, N Ji… - Neuron, 2023 - cell.com
In vivo fluorescence recording techniques have produced landmark discoveries in
neuroscience, providing insight into how single cell and circuit-level computations mediate …

Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling

C Long, K Lee, L Yang, T Dafalias, AK Wu… - Nature …, 2024 - nature.com
Dopaminergic neurons play a crucial role in associative learning, but their capacity to
regulate behavior on subsecond timescales remains debated. It is thought that …

Miniscope-LFOV: a large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals

C Guo, GJ Blair, M Sehgal, FN Sangiuliano Jimka… - Science …, 2023 - science.org
Imaging large-population, single-cell fluorescent dynamics in freely behaving animals larger
than mice remains a key endeavor of neuroscience. We present a large-field-of-view open …

Multiscale imaging informs translational mouse modeling of neurological disease

Y Wang, JM LeDue, TH Murphy - Neuron, 2022 - cell.com
Multiscale neurophysiology reveals that simple motor actions are associated with changes
in neuronal firing in virtually every brain region studied. Accordingly, the assessment of focal …

Offline ensemble co-reactivation links memories across days

Y Zaki, ZT Pennington, D Morales-Rodriguez… - Nature, 2024 - nature.com
Memories are encoded in neural ensembles during learning,,,,–and are stabilized by post-
learning reactivation,,,,,,,,,–. Integrating recent experiences into existing memories ensures …

A perspective on astrocyte regulation of neural circuit function and animal behavior

J Hirrlinger, A Nimmerjahn - Glia, 2022 - Wiley Online Library
Studies over the past two decades have demonstrated that astrocytes are tightly associated
with neurons and play pivotal roles in neural circuit development, operation, and adaptation …

ONIX: a unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior

JP Newman, J Zhang, A Cuevas-López, NJ Miller… - Nature …, 2024 - nature.com
Behavioral neuroscience faces two conflicting demands: long-duration recordings from large
neural populations and unimpeded animal behavior. To meet this challenge we developed …

Hidden state inference requires abstract contextual representations in the ventral hippocampus

K Mishchanchuk, G Gregoriou, A Qü, A Kastler… - Science, 2024 - science.org
The ability to use subjective, latent contextual representations to influence decision-making
is crucial for everyday life. The hippocampus is hypothesized to bind together otherwise …

[HTML][HTML] A unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior

JP Newman, J Zhang, A Cuevas-Lopez, NJ Miller… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Behavioral neuroscience faces two conflicting demands: long-duration recordings from large
neural populations and unimpeded animal behavior. To meet this challenge, we developed …

Syntalos: a software for precise synchronization of simultaneous multi-modal data acquisition and closed-loop interventions

M Klumpp, L Embray, F Heimburg… - Nature …, 2025 - nature.com
Complex experimental protocols often require multi-modal data acquisition with precisely
aligned timing, as well as state-and behavior-dependent interventions. Tailored solutions …