The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …

All multicellular organisms rely on differential gene transcription regulated by genomic
enhancers, which function through cofactors that are recruited by transcription factors …

The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

Recent years have witnessed a sea change in our understanding of transcription regulation:
whereas traditional models focused solely on the events that brought RNA polymerase II …

The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Super-enhancers are an emerging subclass of regulatory regions controlling cell identity
and disease genes. However, their biological function and impact on miRNA networks are …

Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …

ABSTRACT Cyclin-dependent kinase 9 (CDK9) is critical for RNA Polymerase II (Pol II)
transcription initiation, elongation, and termination in several key biological processes …