Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

Phosphoinositide 3-kinases (PI3Ks) generate lipids that control a wide variety of intracellular
signalling pathways. Part of this diversity in PI3K actions stems from the broad range of …

▪ Abstract Cells of the immune system carry out diverse functions that are controlled by
surface receptors for antigen, costimulatory molecules, cytokines, chemokines, and other …

Breast cancer (BC) is the leading cancer in the world in terms of incidence and mortality in
women. However, the mechanism by which BC develops remains largely unknown. The …

Therapy based on Bruton's tyrosine kinase (BTK) inhibitors one of the major treatment
options currently recommended for lymphoma patients. The first generation of BTK inhibitor …

Mouse gene–targeting studies have documented a central role of the p110δ isoform of
phosphoinositide 3-kinase (PI3K) in B-cell development and function. A defect in B-cell …

Store‐operated calcium entry (SOCE) is the main Ca2+ influx pathway involved in
controlling proliferation of the human hepatoma cell lines Huh‐7 and HepG2. However, the …

Bruton's tyrosine kinase (BTK) is an intracellular signaling molecule first identified as the
molecule affected in X-linked agammaglobulinemia (XLA) patients, who almost completely …

Phosphoinositide 3-kinase (PI3K) activation is essential for lymphocyte proliferation driven
by receptors for antigen, costimulatory ligands and cytokines. The lipid products of PI3K …

Cell cycle arrest by FoxO transcription factors involves transcriptional repression of cyclin D,
although the exact mechanism remains unclear. In this study, we used the BCR-ABL …