It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Depression has become one of the most prevalent neuropsychiatric disorders characterized
by anhedonia, anxiety, pessimism, or even suicidal thoughts. Receptor theory has been …

Most prostate cancers express the androgen receptor (AR), and tumor growth and
progression are facilitated by exceptionally low levels of systemic or intratumorally produced …

Transcription factors (TFs) regulate gene expression by binding to specific consensus motifs
within the local chromatin context. The mechanisms by which TFs navigate the nuclear …

How pioneer factors interface with chromatin to promote accessibility for transcription control
is poorly understood in vivo. Here, we directly visualize chromatin association by the …

Human nuclear receptors (NRs) are a superfamily of ligand-responsive transcription factors
that have central roles in cellular function. Their malfunction is linked to numerous diseases …

The glucocorticoid and mineralocorticoid receptors (GR and MR, respectively) have distinct,
yet overlapping physiological and pathophysiological functions. There are indications that …

The glucocorticoid receptor (GR) is a ligand-activated transcription factor that binds DNA
and assembles co-regulator complexes to regulate gene transcription. GR agonists are …

A widely regarded model for glucocorticoid receptor (GR) action postulates that dimeric
binding to DNA regulates unfavorable metabolic pathways while monomeric receptor …

The glucocorticoid receptor (GR) is a bona fide ligand‐regulated transcription factor. Cloned
in the 80s, the GR has become one of the best‐studied and clinically most relevant members …