[图书][B] Bioassay techniques for drug development

MI Choudhary, WJ Thomsen - 2001 - taylorfrancis.com
The goal of an activity-directed isolation process is to isolate bioactive compounds which
may provide structural leads of therapeutic importance. Whereas the traditional process of …

Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line

Y Hoshino, T Mio, S Nagai, H Miki… - American Journal of …, 2001 - journals.physiology.org
Injury of the alveolar epithelium by cigarette smoke is presumed to be an important process
in the pathogenesis of smoking-related pulmonary diseases. We investigated the cytotoxic …

Spectral profiles of cultured neuronal and glial cells derived from HRMAS 1H NMR spectroscopy

JL Griffin, M Bollard, JK Nicholson… - NMR in Biomedicine …, 2002 - Wiley Online Library
In the investigations of brain function and pathology in vivo by magnetic resonance
spectroscopy (MRS), a decrease in the relative concentration of N‐acetyl aspartate (NAA) …

Gradient, high‐resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy of intact cells

P Weybright, K Millis, N Campbell… - Magnetic resonance …, 1998 - Wiley Online Library
The application of new gradient, high‐resolution, magic angle spinning (MAS) 1H nuclear
magnetic resonance (NMR) spectroscopy to the study of intact undifferentiated and …

A novel method of magnetic nanoparticles functionalized with anti-folate receptor antibody and methotrexate for antibody mediated targeted drug delivery

MS Lodhi, F Khalid, MT Khan, ZQ Samra… - Molecules, 2022 - mdpi.com
Therapeutic effects of anticancer medicines can be improved by targeting the specific
receptors on cancer cells. Folate receptor (FR) targeting with antibody (Ab) is an effective …

Genotoxic effects of chromium (VI) and cadmium (II) in human blood lymphocytes using the electron microscopy in situ end-labeling (EM-ISEL) assay

F Depault, M Cojocaru, F Fortin, S Chakrabarti… - Toxicology in vitro, 2006 - Elsevier
Evaluation of genotoxic effects of potassium chromate (K2CrO4) and cadmium chloride
(CdCl2) was carried out in human blood lymphocytes in vitro as measured by the electron …

An MTT‐based method for quantification of periodontal ligament cell viability

E Kim, IS Jeon, JW Kim, J Kim, HS Jung… - Oral Diseases, 2007 - Wiley Online Library
Objective: Survival of periodontal ligament cells is crucial issue after tooth replantation. To
understand this matter, we introduced MTT assay, which can be used as a tool for …

A tetrazolium-based colorimetric assay for metabolic activity of stored blood platelets

Y Maekawa, K Yagi, A Nonomura, R Kuraoku… - Thrombosis research, 2003 - Elsevier
Introduction: Much work has been carried out in an attempt to establish the optimum
cryopreservation of platelets. To estimate the surviving numbers of stored platelets, the …

Modulation of polymorphonuclear cell interleukin-8 secretion by human monoclonal antibodies to type 8 pneumococcal capsular polysaccharide

T Burns, Z Zhong, M Steinitz, L Pirofski - Infection and immunity, 2003 - Am Soc Microbiol
Pneumococcal capsular polysaccharide (PS) vaccines induce type-specific immunoglobulin
M (IgM), IgG, and IgA. Type-specific IgG to the PS is sufficient to confer protection against the …

The MPTP status during early reoxygenation is critical for cardioprotection

MA Husainy, JM Dickenson, M Galiñanes - Journal of Surgical Research, 2012 - Elsevier
BACKGROUND: Previous studies have revealed that the mitochondrial permeability
transition pore (MPTP) plays a critical role in necrotic and apoptotic cell death. Given the …