Therapeutic advances in hormone-dependent cancers: focus on prostate, breast and ovarian cancers
M Ulm, AV Ramesh, KM McNamara… - Endocrine …, 2019 - ec.bioscientifica.com
Hormonal cancers affect over 400,000 men and women, and contribute collectively to over
100,000 deaths in the United States alone. Thanks to advances in the understanding of …
100,000 deaths in the United States alone. Thanks to advances in the understanding of …
Recent advancements in aptamer-bioconjugates: sharpening stones for breast and prostate cancers targeting
Breast and prostate cancers are common types of cancers with various strategies, such as
chemotherapy and radiotherapy, for their therapy. Since these methods have undesired side …
chemotherapy and radiotherapy, for their therapy. Since these methods have undesired side …
Long noncoding RNA LINC02418 regulates MELK expression by acting as a ceRNA and may serve as a diagnostic marker for colorectal cancer
Y Zhao, T Du, L Du, P Li, J Li, W Duan, Y Wang… - Cell death & …, 2019 - nature.com
Some types of long noncoding RNAs (lncRNAs) are aberrantly expressed in human
diseases, including cancer. However, the overall biological roles and clinical significances …
diseases, including cancer. However, the overall biological roles and clinical significances …
Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia
Y Zhang, X Zhou, Y Li, Y Xu, K Lu, P Li, X Wang - Oncogene, 2018 - nature.com
TP53 pathway defects contributed to therapy resistance and adverse clinical outcome in
chronic lymphocytic leukemia (CLL), which represents an unmet clinical need with few …
chronic lymphocytic leukemia (CLL), which represents an unmet clinical need with few …
EZH2 phosphorylation promotes self-renewal of glioma stem-like cells through NF-κB methylation
H Liu, Y Sun, X Qi, RE Gordon, JA O'Brien… - Frontiers in …, 2019 - frontiersin.org
Cancer stem-like cells (CSCs) is a cell population in glioma with capacity of self-renewal
and is critical in glioma tumorigenesis. Parallels between CSCs and normal stem cells …
and is critical in glioma tumorigenesis. Parallels between CSCs and normal stem cells …
Bacteriophages M13 and T4 increase the expression of anchorage-dependent survival pathway genes and down regulate androgen receptor expression in LNCaP …
SG Sanmukh, NJ Dos Santos, CN Barquilha… - Viruses, 2021 - mdpi.com
Wild-type or engineered bacteriophages have been reported as therapeutic agents in the
treatment of several types of diseases, including cancer. They might be used either as naked …
treatment of several types of diseases, including cancer. They might be used either as naked …
Maternal embryonic leucine zipper kinase in tumor cells and tumor microenvironment: An emerging player and promising therapeutic opportunity
BF Tang, RC Yan, SW Wang, ZC Zeng, SS Du - Cancer Letters, 2023 - Elsevier
Maternal embryonic leucine zipper kinase (MELK) is a member of the AMPK (AMP-activated
protein kinase) protein family, which is widely and highly expressed in multiple cancer types …
protein kinase) protein family, which is widely and highly expressed in multiple cancer types …
Inhibition of MELK produces potential anti‐tumour effects in bladder cancer by inducing G1/S cell cycle arrest via the ATM/CHK2/p53 pathway
S Chen, Q Zhou, Z Guo, Y Wang… - Journal of Cellular …, 2020 - Wiley Online Library
We aimed to investigate the biological function of MELK and the therapeutic potential of
OTSSP167 in human bladder cancer (BCa). First, we observed overexpression of MELK in …
OTSSP167 in human bladder cancer (BCa). First, we observed overexpression of MELK in …
[HTML][HTML] Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner
The treatment of advanced prostate cancer remains a formidable challenge due to the
limited availability of effective treatment options. Therefore, it is imperative to identify …
limited availability of effective treatment options. Therefore, it is imperative to identify …
[HTML][HTML] Identification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition
SAA Santos, ACL Camargo, FB Constantino… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
The developmental origins of health and disease concept links adult diseases with early-life
exposure to inappropriate environmental conditions. Intrauterine and postnatal malnutrition …
exposure to inappropriate environmental conditions. Intrauterine and postnatal malnutrition …