HIV genome-wide protein associations: a review of 30 years of research

G Li, E De Clercq - Microbiology and Molecular Biology Reviews, 2016 - Am Soc Microbiol
The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

Exploring the potentiality of natural products from essential oils as inhibitors of odorant-binding proteins: A structure-and ligand-based virtual screening approach to …

KS da Costa, JM Galúcio, CHS da Costa… - ACS …, 2019 - ACS Publications
Odorant-binding proteins (OBPs) are the main olfactory proteins of mosquitoes, and their
structures have been widely explored to develop new repellents. In the present study, we …

Structural, energetic and lipophilic analysis of SARS-CoV-2 non-structural protein 9 (NSP9)

J de O. Araújo, S Pinheiro, WJ Zamora, CN Alves… - Scientific Reports, 2021 - nature.com
In SARS-CoV-2 replication complex, the Non-structural protein 9 (Nsp9) is an important RNA
binding subunit in the RNA-synthesizing machinery. The dimeric forms of coronavirus Nsp9 …

Epigenetic association study uncovered H3K27 acetylation enhancers and dysregulated genes in high-fat-diet-induced nonalcoholic fatty liver disease in rats

J Ma, D You, S Chen, N Fang, X Yi, Y Wang, X Lu… - …, 2022 - Taylor & Francis
Aim: To evaluate the regulatory landscape underlying the active enhancer marked by
H3K27ac in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) in rats …

Virtual screening of natural products against 5-enolpyruvylshikimate-3-phosphate synthase using the Anagreen herbicide-like natural compound library

MVD de Oliveira, GMB Fernandes, KS da Costa… - RSC …, 2022 - pubs.rsc.org
The shikimate pathway enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS)
catalyzes a reaction involved in the production of amino acids essential for plant growth and …

Targeting shikimate pathway: In silico analysis of phosphoenolpyruvate derivatives as inhibitors of EPSP synthase and DAHP synthase

MD de Oliveira, JO Araujo, JMP Galúcio… - Journal of Molecular …, 2020 - Elsevier
The shikimate pathway consists of seven enzymatic steps involved in the conversion of
erythrose-4-phosphate and phosphoenolpyruvate to chorismate and also responsible to the …

Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae

H Chen, R Zhang, RH Luo, LM Yang, RR Wang… - Molecules, 2017 - mdpi.com
APOBEC3G is a member of the human cytidine deaminase family that restricts Vif-deficient
viruses by being packaged with progeny virions and inducing the G to A mutation during the …

In silico identification of natural products with anticancer activity using a chemo-structural database of Brazilian biodiversity

JM Galúcio, EF Monteiro, DA de Jesus… - … biology and chemistry, 2019 - Elsevier
Cancer is one of the leading causes of death worldwide, and the number of patients has
only increased each year, despite the considerable efforts and investments in scientific …

Analysis of kojic acid derivatives as competitive inhibitors of tyrosinase: a molecular modeling approach

R Cardoso, R Valente, CH Souza da Costa… - Molecules, 2021 - mdpi.com
Tyrosinases belong to the functional copper-containing proteins family, and their structure
contains two copper atoms, in the active site, which are coordinated by three histidine …

Structural and evolutionary analysis of Leishmania Alba proteins

KS da Costa, JMP Galúcio, ES Leonardo… - Molecular and …, 2017 - Elsevier
The Alba superfamily proteins share a common RNA-binding domain. These proteins
participate in a variety of regulatory pathways by controlling developmental gene …