The phospholipase A2 superfamily: structure, isozymes, catalysis, physiologic and pathologic roles
The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester
bond at the sn-2 position of the phospholipids, generating a free fatty acid and a …
bond at the sn-2 position of the phospholipids, generating a free fatty acid and a …
Kainic acid-mediated excitotoxicity as a model for neurodegeneration
Neuronal excitation involving the excitatory glutamate receptors is recognized as an
important underlying mechanism in neurodegenerative disorders. Excitation resulting from …
important underlying mechanism in neurodegenerative disorders. Excitation resulting from …
Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases
Phospholipase A 2 (PLA 2) belongs to a family of enzymes that catalyze the cleavage of fatty
acids from the sn-2 position of phospholipids. There are more than 19 different isoforms of …
acids from the sn-2 position of phospholipids. There are more than 19 different isoforms of …
Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons
PB Shelat, M Chalimoniuk, JH Wang… - Journal of …, 2008 - Wiley Online Library
Increase in oxidative stress has been postulated to play an important role in the
pathogenesis of a number of neurodegenerative diseases including Alzheimer's disease …
pathogenesis of a number of neurodegenerative diseases including Alzheimer's disease …
Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke
The significance of the hypoxia component of stroke injury is highlighted by hypermetabolic
brain tissue enriched with arachidonic acid (AA), a 22: 6n-3 polyunsaturated fatty acid. In an …
brain tissue enriched with arachidonic acid (AA), a 22: 6n-3 polyunsaturated fatty acid. In an …
Roles of eicosanoids in regulating inflammation and neutrophil migration as an innate host response to bacterial infections
AEF Sheppe, MJ Edelmann - Infection and Immunity, 2021 - Am Soc Microbiol
Eicosanoids are lipid-based signaling molecules that play a unique role in innate immune
responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and …
responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and …
P2 receptors: intracellular signaling
P2 receptors for extracellular nucleotides are divided into two categories: the ion channel
receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal …
receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal …
Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor
NG Bazan - Journal of lipid research, 2003 - ASBMB
Neuronal cellular and intracellular membranes are rich in specialized phospholipids that are
reservoirs of lipid messengers released by specific phospholipases and stimulated by …
reservoirs of lipid messengers released by specific phospholipases and stimulated by …
Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP …
M Strokin, M Sergeeva, G Reiser - British journal of …, 2003 - Wiley Online Library
Docosahexaenoic acid (DHA) and arachidonic acid (AA), polyunsaturated fatty acids
(PUFAs), are important for central nervous system function during development and in …
(PUFAs), are important for central nervous system function during development and in …
Phospholipases A2 and inflammatory responses in the central nervous system
Abstract Phospholipases A2 (PLA2s) belong to a superfamily of enzymes responsible for
hydrolyzing the sn-2 fatty acids of membrane phospholipids. These enzymes are known to …
hydrolyzing the sn-2 fatty acids of membrane phospholipids. These enzymes are known to …