Recent proteome and transcriptome profiling of Alzheimer's disease (AD) brains reveals
RNA splicing dysfunction and U1 small nuclear ribonucleoprotein (snRNP) pathology …

Protein aggregation of amyloid-β peptides and tau are pathological hallmarks of Alzheimer's
disease (AD), which are often resistant to detergent extraction and thus enriched in the …

Nutrient availability and organelle biology direct tissue homeostasis and cell fate, but how
these processes orchestrate tissue immunity remains poorly defined. Here, using in vivo …

Abstract Background: Mass spectrometry (MS)‐based proteomic analysis of
posttranslational modifications (PTMs) usually requires the pre‐enrichment of modified …

Alzheimer's disease (AD) is the most prevalent form of dementia, disproportionately affecting
women in disease prevalence and progression. Comprehensive analysis of the serum …

Regulation of the immune response to Salmonella enterica serovar Typhimurium (S.
Typhimurium) infection is a complex process, influenced by the interaction between genetic …

Inflammation can impair intestinal barrier, while increased epithelial permeability can lead to
inflammation. In this study, we found that the expression of Tspan8, a tetraspanin expressed …

Simple Summary With the influx of multi-omics profiling, effective integration of these data
remains the bottleneck for omics-driven discovery. Thus, we developed DRPPM-EASY, an R …

Blood in the circulatory system carries information of physiological and pathological status of
the human body, so blood proteins are often used as biomarkers for diagnosis, prognosis …

Single-cell-type proteomics is an emerging field of research that combines cell-type
specificity with the comprehensive proteome coverage offered by bulk proteomics. However …