Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity
CY Liu, CL Ahonen, ME Brown, L Zhou, M Welin… - MAbs, 2023 - Taylor & Francis
Bispecific antibodies continue to represent a growth area for antibody therapeutics, with
roughly a third of molecules in clinical development being T-cell engagers that use an anti …
roughly a third of molecules in clinical development being T-cell engagers that use an anti …
[HTML][HTML] Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for …
R Yadav, S Sukumaran, J Lutman, MS Mitra… - Journal of …, 2023 - Elsevier
MTBT1466A is a high-affinity TGFβ3-specific humanized IgG1 monoclonal antibody with
reduced Fc effector function, currently under investigation in clinical trials as a potential anti …
reduced Fc effector function, currently under investigation in clinical trials as a potential anti …
[HTML][HTML] Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma
RP O'Connell, K Liaw, N Wellhausen… - … for Immunotherapy of …, 2024 - ncbi.nlm.nih.gov
Background Advanced clear cell renal cell carcinoma (ccRCC) is a prevalent kidney cancer
for which long-term survival rates are abysmal, though immunotherapies are showing …
for which long-term survival rates are abysmal, though immunotherapies are showing …
[HTML][HTML] Development of therapeutic monoclonal antibodies against DKK1 peptide-HLA-A2 complex to treat human cancers
Background Targeted immunotherapy with monoclonal antibodies (mAbs) is an effective
and safe method for the treatment of malignancies. Development of mAbs with improved …
and safe method for the treatment of malignancies. Development of mAbs with improved …
Target-Mediated Drug Disposition (TMDD) in Pharmacokinetics and Pharmacodynamics (PK/PD) of Large-Molecule and Small-Molecule Compounds
N Wu - 2023 - search.proquest.com
Target-mediated drug disposition (TMDD) represents a pivotal phenomenon in
pharmacology, where the interaction between a potent drug and its pharmacological target …
pharmacology, where the interaction between a potent drug and its pharmacological target …
Model-Based Decision Making in Life Sciences
M Sadeghi - 2022 - search.proquest.com
Mathematical models are key tools in rational decision-making processes. A" good" model is
expected to reproduce experimental observations, which enables predictions outside the …
expected to reproduce experimental observations, which enables predictions outside the …